Alternative surface functionalization of nanoparticles for biomedical application



6 Jul 2017 to 8 Jul 2017


University of Cologne

In the field of nanomedicine, the functionalization of nanoparticles as well as nanostructured surfaces in general is of crucial importance as it influences their biocompatibility, blood circulation time and their ability to cross biological barriers. Therefore, several grafting techniques have been developed to attach functional molecules such as biodegradable polymers or targeting units, which have been proven to significantly enhance cellular uptake, to the surface of nanoparticles. However, controlling the stoichiometric linkage of two or more ligands to one particle still remains a major challenge. Particles which possess a surface anisotropy, so called Janus particles, offer different chemical properties which can sensitively be targeted. A common method to prepare these kind of particles is based on a monolayer of nanoparticles on a substrate which gets exposed to metal or metal oxide via sputtering. Nevertheless, this physical vapor deposition methods results in formation of metal or metal oxide particles on the particle surface. In contrast to that, the employment of atomic layer deposition is expected to enable the homogenous coating of particles on their exposed sides with an unprecedented control of thickness and homogeneity. This workshop aims to create a platform where the experts on both field (biomedical and ALD) can discuss the problem and future of he alternative functionalization of nanoparticles and biosurfaces for biomedical applications.